Laboratories performing food safety and authenticity, pharmaceutical, metabolomic, anti-doping and other analyses using gas chromatography-mass spectrometry (GC-MS) can now achieve new levels of performance using high-resolution accurate-mass (HRAM) Orbitrap mass spectrometry, bringing the highest level of detection and identification capabilities to GC-MS studies.
The new Thermo Scientific Q Exactive GC hybrid quadrupole-Orbitrap GC-MS/MS instrument represents the first commercial system offering a combination of gas chromatography and HRAM Orbitrap mass spectrometry. This system is designed to provide the comprehensive characterization of samples in a single analysis for increased performance in compound discovery, identification and quantitation.
“Scientists all over the world have made tremendous scientific progress over the past decade using Orbitrap-based mass spectrometry with liquid chromatography,” said Sergio Guazzotti, Director of Marketing, GC-MS, Thermo Fisher Scientific. “Now, we are unlocking the power of Orbitrap technology for gas chromatography, providing GC-MS users with high resolving power and mass accuracy to deliver a deeper understanding of their samples than ever before.”
Early field collaborations with scientific leaders explored the application of this technology for both research and applied laboratories. Professor Joshua Coon, PhD, University of Wisconsin, Madison, applies GC-MS to metabolomic studies to understand complex biological systems. “While the LC-MS field has advanced rapidly over the past several years, largely driven by the impact of the Orbitrap mass analyzer, GC-MS could not offer comparable mass resolution and accuracy,” said Dr. Coon. “The introduction of the Q Exactive GC system is a game changer in this space. The combination of fast, predictable GC separations with accurate mass capabilities will translate to an increased ability to profile entire metabolomes.”
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